LUBBOCK, Texas, Sept. 11 (UPI) -- A recently patented
chemical additive could make old antibiotics effective again against
resistant bacteria, a Texas Tech researcher said.
A short chain of nucleic acid, called an aptamer, can stop
antibiotic-resistant bacteria from breaking down antibiotics, said
Robert Shaw, associate chairman of Texas Tech's Department of
Chemistry.
Aptamers could invigorate beta-lactam antibiotics, such as
penicillins, carbapenems and cephalosporins, which account for
nearly $30 billion in annual sales in the United States and more
worldwide, Shaw said in a release.
Aptamers used with antibiotics kill bacteria that produce
enzymes called metallo-beta-lactamase, which have been the most
difficult enzymes for researchers to counteract, Shaw said.
Bacteria become antibiotic-resistant when they exchange
genetic information on how to make these enzymes, Shaw said in an
edition of Chemical Biology and Drug Design covering the best
presentations of the 2008 International Symposium on Organic
Synthesis and Drug Discovery.